Vitamin D endocrine physiology

Robert P. Heaney

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Quantitative aspects of vitamin D3 endocrine physiology are briefly reviewed, together with the supporting evidence. Net calcium absorption of at least 200 mg/d is required to offset typical obligatory losses and thereby to protect the skeleton. The ability of the body to regulate intestinal calcium absorption is optimal at serum 25-hydroxyvitamin D3 concentrations >80 nM. Vitamin D3 inputs from all sources required to sustain such a level amount to 3600-4200 IU/d. Daily oral intakes as high as 10,000 IU are safe.

Original languageEnglish (US)
Pages (from-to)V25-V27
JournalJournal of Bone and Mineral Research
Issue numberSUPPL. 2
StatePublished - Dec 2007

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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