Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance

Elizabeth G. Munro; Maneesh Jain; Esther Oliva; Neel Kamal; Subodh M. Lele; Maureen P. Lynch; Lankai Guo; Kai Fu; Poonam Sharma; Steve Remmenga; Whitfield B. Growdon; John S. Davis; Bo R. Rueda; Surinder K. Batra

doi:10.1097/PGP.0b013e318184f3e0

Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance

Elizabeth G. Munro, Maneesh Jain, Esther Oliva, Neel Kamal, Subodh M. Lele, Maureen P. Lynch, Lankai Guo, Kai Fu, Poonam Sharma, Steve Remmenga, Whitfield B. Growdon, John S. Davis, Bo R. Rueda, Surinder K. Batra

Department of Pathology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

MUC4 is a transmembrane glycoprotein more highly expressed in cervical dysplasia than benign cervical epithelium. We sought to determine whether MUC4 expression differs between benign and malignant cervical tissue. Fifty-eight patients with benign, dysplastic, or malignant cervical pathology were identified retrospectively, and representative sections were stained with a mouse monoclonal anti-MUC4 antibody. Semiquantitative analysis was performed on benign, dysplastic, and malignant regions by scoring staining intensity (0: negative, 1: weak, 2: moderate, and 3: strong) and distribution (focal

Original language	English (US)
Pages (from-to)	127-133
Number of pages	7
Journal	International Journal of Gynecological Pathology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1097/PGP.0b013e318184f3e0
State	Published - Mar 2009

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Obstetrics and Gynecology

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Munro, E. G., Jain, M., Oliva, E., Kamal, N., Lele, S. M., Lynch, M. P., Guo, L., Fu, K., Sharma, P., Remmenga, S., Growdon, W. B., Davis, J. S., Rueda, B. R., & Batra, S. K. (2009). Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance. International Journal of Gynecological Pathology, 28(2), 127-133. https://doi.org/10.1097/PGP.0b013e318184f3e0

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abstract = "MUC4 is a transmembrane glycoprotein more highly expressed in cervical dysplasia than benign cervical epithelium. We sought to determine whether MUC4 expression differs between benign and malignant cervical tissue. Fifty-eight patients with benign, dysplastic, or malignant cervical pathology were identified retrospectively, and representative sections were stained with a mouse monoclonal anti-MUC4 antibody. Semiquantitative analysis was performed on benign, dysplastic, and malignant regions by scoring staining intensity (0: negative, 1: weak, 2: moderate, and 3: strong) and distribution (focal ",

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AU - Jain, Maneesh

AU - Oliva, Esther

AU - Kamal, Neel

AU - Lele, Subodh M.

AU - Lynch, Maureen P.

AU - Guo, Lankai

AU - Fu, Kai

AU - Sharma, Poonam

AU - Remmenga, Steve

AU - Growdon, Whitfield B.

AU - Davis, John S.

AU - Rueda, Bo R.

AU - Batra, Surinder K.

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AB - MUC4 is a transmembrane glycoprotein more highly expressed in cervical dysplasia than benign cervical epithelium. We sought to determine whether MUC4 expression differs between benign and malignant cervical tissue. Fifty-eight patients with benign, dysplastic, or malignant cervical pathology were identified retrospectively, and representative sections were stained with a mouse monoclonal anti-MUC4 antibody. Semiquantitative analysis was performed on benign, dysplastic, and malignant regions by scoring staining intensity (0: negative, 1: weak, 2: moderate, and 3: strong) and distribution (focal

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Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance

Abstract

All Science Journal Classification (ASJC) codes

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