Upper urinary tract carcinoma in lynch syndrome cases

David G. Crockett, David G. Wagner, Sten Holmng, Sonny L. Johansson, Henry T. Lynch

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Purpose Patients with Lynch syndrome are much more likely to have generally rare upper urinary tract urothelial carcinoma but not bladder urothelial carcinoma. While the risk has been quantified, to our knowledge there is no description of how this population of patients with Lynch syndrome and upper urinary tract cancer differs from the general population with upper urinary tract cancer. Materials and Methods We obtained retrospective data on a cohort of patients with Lynch syndrome from the Hereditary Cancer Center in Omaha, Nebraska and compared the data to those on a control general population from western Sweden. These data were supplemented by a new survey about exposure to known risk factors. Results Of the patients with Lynch syndrome 91% had mutations in MSH2 rather than in MSH1 and 79% showed upper tract urothelial carcinoma a mean of 15.85 years after prior Lynch syndrome-type cancer. Median age at diagnosis was 62 years vs 70 in the general population (p

Original languageEnglish (US)
Pages (from-to)1627-1630
Number of pages4
JournalJournal of Urology
Issue number5
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Urology


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