Therapeutic ultrasound-enhanced thrombolysis in patients with acute myocardial infarction

Xuedong Shen; Chandra Nair; Mark Holmberg; Aryan Mooss; Amy Arouni; Dennis Esterbrooks

doi:10.1177/0003319709343287

Therapeutic ultrasound-enhanced thrombolysis in patients with acute myocardial infarction

Xuedong Shen, Chandra Nair, Mark Holmberg, Aryan Mooss, Amy Arouni, Dennis Esterbrooks

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.

Original language	English (US)
Pages (from-to)	253-258
Number of pages	6
Journal	Angiology
Volume	61
Issue number	3
DOIs	https://doi.org/10.1177/0003319709343287
State	Published - Jun 1 2010

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1177/0003319709343287

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abstract = "Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.",

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AU - Nair, Chandra

AU - Holmberg, Mark

AU - Mooss, Aryan

AU - Arouni, Amy

AU - Esterbrooks, Dennis

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N2 - Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.

AB - Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.

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Therapeutic ultrasound-enhanced thrombolysis in patients with acute myocardial infarction

Abstract

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