TY - JOUR
T1 - The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer
T2 - clinical and pathologic features
AU - Locker, Gershon Y.
AU - Kaul, Karen
AU - Weinberg, David S.
AU - Gatalica, Zoran
AU - Gong, Gordon
AU - Peterman, Amy
AU - Lynch, Jane
AU - Klatzco, Lucy
AU - Olopade, Olufunmilayo I.
AU - Bomzer, Charles A.
AU - Newlin, Anna
AU - Keenan, Eileen
AU - Tajuddin, Mohammed
AU - Knezetic, Joseph
AU - Coronel, Stephanie
AU - Lynch, Henry T.
N1 - Funding Information:
We wish to acknowledge the invaluable help of Susan Nelson, RN, for administrative support of this study and of Carey A. Cullinane, MD, and Patricia Gambol, RN, for patient enrollment and genetic counseling. This project was supported by NIH NCI Grant R01 CA080179.
PY - 2006/8
Y1 - 2006/8
N2 - Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6-7% of Ashkenazi Jews and increases the risk of colorectal cancer. This study aimed to describe the clinical, pathologic and epidemiologic features of colorectal cancer in I1307K carriers to determine whether there were any features which might warrant individual screening for the mutation. In all, 215 Ashkenazi Jews with a personal history of colorectal cancer were enrolled. Clinical and family history, pathology reports, and slides were obtained and blood drawn for I1307K determination. The presence of the mutation was determined by PCR from white blood cell DNA. Colorectal cancer pathology slides were read in a blinded fashion. Of the 215 enrolled patients, 26 (12.1%) tested positive for I1307K. There was no difference in the pathologic features between colorectal cancers in Ashkenazi carriers compared to noncarriers. There was no difference in the age at diagnosis or history of second or other primaries. Carriers had an increased likelihood of having a first-degree relative with colorectal cancer (50%) compared to noncarriers (28%, P <0.04). We could find no distinguishing feature other than family history that characterizes I1307K positive colorectal cancers. We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I1307K would be clinically useful.
AB - Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6-7% of Ashkenazi Jews and increases the risk of colorectal cancer. This study aimed to describe the clinical, pathologic and epidemiologic features of colorectal cancer in I1307K carriers to determine whether there were any features which might warrant individual screening for the mutation. In all, 215 Ashkenazi Jews with a personal history of colorectal cancer were enrolled. Clinical and family history, pathology reports, and slides were obtained and blood drawn for I1307K determination. The presence of the mutation was determined by PCR from white blood cell DNA. Colorectal cancer pathology slides were read in a blinded fashion. Of the 215 enrolled patients, 26 (12.1%) tested positive for I1307K. There was no difference in the pathologic features between colorectal cancers in Ashkenazi carriers compared to noncarriers. There was no difference in the age at diagnosis or history of second or other primaries. Carriers had an increased likelihood of having a first-degree relative with colorectal cancer (50%) compared to noncarriers (28%, P <0.04). We could find no distinguishing feature other than family history that characterizes I1307K positive colorectal cancers. We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I1307K would be clinically useful.
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U2 - 10.1016/j.cancergencyto.2006.03.007
DO - 10.1016/j.cancergencyto.2006.03.007
M3 - Article
C2 - 16875934
AN - SCOPUS:33746216907
SN - 0165-4608
VL - 169
SP - 33
EP - 38
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -