The effect of L-arginine on absorption of a glucose-electrolyte solution in humans

G. Patrick Lambert, James Lang, Rebecca Welch, Stephen Lanspa

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to determine the effect of a low concentration of L-arginine (Arg) on water absorption from an isotonic glucose-electrolyte solution (GES). Six healthy human subjects (mean ± SD age = 23 ± 2 yr) participated. The GES tested were 222 mM glucose (G), 222 mM glucose + 1.5 mM Arg (G + 1.5 Arg), and 222 mM glucose + 3 mM Arg (G + 3 Arg). To control for the effect of glucose on water absorption, a 222 mM fructose + 1.5 mM Arg (F + 1.5 Arg) solution was also tested. Solutions also contained 20 mEq sodium and 3 mEq potassium (osmolalites = ~270 mOsm/kgH2O). Water absorption was not different among G, G + 1.5 Arg, and G + 3 Arg. The respective medians (ranges) for those solutions were 5.5 (4.1 to 9.7), 6.6 (2.3 to 7.9), and 5.8 (3.9 to 13.6) ml/h/cm. Each of the glucose-containing solutions promoted faster (P=0.05) absorption than F + 1.5 Arg, which had an absorption rate of 0.8 (-1.7 to 3.0) ml/h/cm. These results indicate water absorption from an isotonic GES in healthy humans is not affected by addition of low concentrations of Arg (1.5 to 3 mM).

Original languageEnglish (US)
Pages (from-to)75-86
Number of pages12
JournalJournal of Exercise Physiology Online
Issue number4
StatePublished - Aug 1 2011

All Science Journal Classification (ASJC) codes

  • Physiology (medical)


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