The cancer syndrome: A status report

H. T. Lynch, P. M. Lynch, W. A. Albano, J. F. Lynch

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


We have described the cancer family syndrome (CFS) from the standpoint of its tumor spectrum, inheritance, and natural history, emphasizing the search for reliable biomarkers of the genotype. Our discussion of surveillance and management has stressed the need to incorporate knowledge of the natural history and genetics of the CFS. Many problems exist in comprehending this disease. Specifically, there exists the possibility that the CFS may merely be a 'catch-all' for several genotypically distinct cancer-predisposing disorders. In accord with the supposition of genetic heterogeneity, the laboratory markers described may eventually enable discrimination of multiple genotypes whose tumor spectra may differ from one entity to another.

Original languageEnglish (US)
Pages (from-to)311-322
Number of pages12
JournalDiseases of the Colon and Rectum
Issue number4
StatePublished - Jan 1 1981

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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