Synthesis and Opioid Activity of Dynorphin A-(1–13)NH₂ Analogues Containing cis- and trans-4-Aminocyclohexanecarboxylic Acid

Medicine & Life Sciences

• dynorphin (1-13) 100%
• Dynorphins 81%
• Opioid Analgesics 52%
• Hydrogenation 32%
• Solid-Phase Synthesis Techniques 32%
• 4-Aminobenzoic Acid 30%
• Radioligand Assay 26%
• Opioid Receptors 22%
• Ileum 20%
• Inhibitory Concentration 50 18%
• Guinea Pigs 17%
• Peptides 12%
• 4-aminocyclohexanecarboxylic acid 9%
• Proteins 7%

Chemical Compounds

• Dynorphin A 96%
• Radioligand 22%
• Cis Isomer 21%
• Trans Isomer 21%
• Acid 20%
• Molecular Modeling 17%
• Hydrogenation 14%
• Peptide 11%
• Aqueous Solution 10%
• Protein 8%