Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Zhiying Wang; Liangqiao Bian; Chenglin Mo; Hui Shen; Lan Juan Zhao; Kuan Jui Su; Maciej Kukula; Jauh Tzuoh Lee; Daniel W. Armstrong; Robert Recker; Joan Lappe; Lynda F. Bonewald; Hong Wen Deng; Marco Brotto

doi:10.1038/s42003-020-0766-y

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Zhiying Wang, Liangqiao Bian, Chenglin Mo, Hui Shen, Lan Juan Zhao, Kuan Jui Su, Maciej Kukula, Jauh Tzuoh Lee, Daniel W. Armstrong, Robert Recker, Joan Lappe, Lynda F. Bonewald, Hong Wen Deng, Marco Brotto

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Abstract

Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60–80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.

Original language	English (US)
Article number	39
Journal	Communications Biology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/s42003-020-0766-y
State	Published - Dec 1 2020

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1038/s42003-020-0766-y

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@article{389a9d482327476bae09d164c36f3ad5,

title = "Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis",

abstract = "Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60–80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.",

author = "Zhiying Wang and Liangqiao Bian and Chenglin Mo and Hui Shen and Zhao, {Lan Juan} and Su, {Kuan Jui} and Maciej Kukula and Lee, {Jauh Tzuoh} and Armstrong, {Daniel W.} and Robert Recker and Joan Lappe and Bonewald, {Lynda F.} and Deng, {Hong Wen} and Marco Brotto",

note = "Funding Information: We are grateful for instrumentation support from Shimadzu Scientific Instruments, Inc. This work was supported by NIH-National Institutes of Aging PO1 AG039355 (L.B., M. B.), and R01AG056504 and R01 AG060341 (M.B.), and the George W. and Hazel M. Jay and Evanston Research Endowments (MB). H.S., L.J.Z., K.S., and H.W.D. were partially supported by grants from National Institutes of [R01AR059781, P20GM109036, R01MH107354, R01MH104680, R01GM109068, R01AR069055, U19AG055373, R01DK115679] the Edward G. Schlieder Endowment and the Drs. W.C. Tsai and P.T. Kung Endowment to Tulane University. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

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doi = "10.1038/s42003-020-0766-y",

language = "English (US)",

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T1 - Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

AU - Wang, Zhiying

AU - Bian, Liangqiao

AU - Mo, Chenglin

AU - Shen, Hui

AU - Zhao, Lan Juan

AU - Su, Kuan Jui

AU - Kukula, Maciej

AU - Lee, Jauh Tzuoh

AU - Armstrong, Daniel W.

AU - Recker, Robert

AU - Lappe, Joan

AU - Bonewald, Lynda F.

AU - Deng, Hong Wen

AU - Brotto, Marco

N1 - Funding Information: We are grateful for instrumentation support from Shimadzu Scientific Instruments, Inc. This work was supported by NIH-National Institutes of Aging PO1 AG039355 (L.B., M. B.), and R01AG056504 and R01 AG060341 (M.B.), and the George W. and Hazel M. Jay and Evanston Research Endowments (MB). H.S., L.J.Z., K.S., and H.W.D. were partially supported by grants from National Institutes of [R01AR059781, P20GM109036, R01MH107354, R01MH104680, R01GM109068, R01AR069055, U19AG055373, R01DK115679] the Edward G. Schlieder Endowment and the Drs. W.C. Tsai and P.T. Kung Endowment to Tulane University. Publisher Copyright: © 2020, The Author(s).

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60–80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.

AB - Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60–80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.

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DO - 10.1038/s42003-020-0766-y

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VL - 3

JO - Communications Biology

JF - Communications Biology

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M1 - 39

ER -

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

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