Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

Angelo Trapani; Norio Matsuki; Peter W. Abel; Kent Hermsmeyer

doi:10.1016/0014-2999(81)90301-0

Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

Angelo Trapani, Norio Matsuki, Peter W. Abel, Kent Hermsmeyer

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Membrane potential (E_m) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an E_m signal in the rabbit ear artery.

Original language	English (US)
Pages (from-to)	87-91
Number of pages	5
Journal	European Journal of Pharmacology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(81)90301-0
State	Published - Jun 10 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0014-2999(81)90301-0

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@article{86afd6da68fd464585d544394fbd33a5,

title = "Norepinephrine produces tension through electromechanical coupling in rabbit ear artery",

abstract = "Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.",

author = "Angelo Trapani and Norio Matsuki and Abel, {Peter W.} and Kent Hermsmeyer",

note = "Funding Information: * Supported by grants HL 16328 and HL 14388 and by Research Career Development Award HL 00073 from the National Institutes of Health. ** To whom correspondence should be addressed: Department of Pharmacology, University of Iowa BSB, Iowa City, Iowa 52242, U.S.A.",

year = "1981",

month = jun,

day = "10",

doi = "10.1016/0014-2999(81)90301-0",

language = "English (US)",

volume = "72",

pages = "87--91",

journal = "European Journal of Pharmacology",

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T1 - Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

AU - Trapani, Angelo

AU - Matsuki, Norio

AU - Abel, Peter W.

AU - Hermsmeyer, Kent

N1 - Funding Information: * Supported by grants HL 16328 and HL 14388 and by Research Career Development Award HL 00073 from the National Institutes of Health. ** To whom correspondence should be addressed: Department of Pharmacology, University of Iowa BSB, Iowa City, Iowa 52242, U.S.A.

PY - 1981/6/10

Y1 - 1981/6/10

N2 - Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

AB - Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

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EP - 91

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

Abstract

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