TY - JOUR
T1 - Neuropeptide γ‐(l‐9)‐Peptide
T2 - A Major Product of the Posttranslational Processing of γ‐Preprotachykinin in Rat Tissues
AU - Wang, Yunxia
AU - Bockman, Charles S.
AU - Lovas, Sandor
AU - Abel, Peter W.
AU - Murphy, Richard F.
AU - Conlon, J. Michael
PY - 1993/10
Y1 - 1993/10
N2 - γ-Preprotachykinin mRNA is the most abundant tachykinin mRNA in rat tissues, but the pathway of posttranslational processing of its translation product is unknown. An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide γ-(1-9)-peptide, equivalent to γ-preprotachykinin-(72-80)-peptide], that showed 70-Arg71 in γ- preprotachykinin is a major site of posttranslational processing, but the resulting product, neuropeptide γ-(1-9)-peptide, is neither an agonist nor an antagonist at the neurokinin-2 (NK-2) receptor.
AB - γ-Preprotachykinin mRNA is the most abundant tachykinin mRNA in rat tissues, but the pathway of posttranslational processing of its translation product is unknown. An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide γ-(1-9)-peptide, equivalent to γ-preprotachykinin-(72-80)-peptide], that showed 70-Arg71 in γ- preprotachykinin is a major site of posttranslational processing, but the resulting product, neuropeptide γ-(1-9)-peptide, is neither an agonist nor an antagonist at the neurokinin-2 (NK-2) receptor.
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U2 - 10.1111/j.1471-4159.1993.tb13613.x
DO - 10.1111/j.1471-4159.1993.tb13613.x
M3 - Article
C2 - 8376981
AN - SCOPUS:0027490895
SN - 0022-3042
VL - 61
SP - 1231
EP - 1235
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 4
ER -