TY - JOUR
T1 - Natural polyphenols
T2 - Potential in the prevention of sexually transmitted viral infections
AU - Date, Abhijit A.
AU - Destache, Christopher J.
N1 - Funding Information:
This work was supported by in part by National Institute of Allergy & Infections Diseases grant ( NIAID ) R01AI117740-01 2015–2019 (to C.J.D.), LB692 Clinical Translational Science Research Grant (to A.D.) and The Dr. George F. Haddix President's Faculty Research Fund (to A.D.).
Publisher Copyright:
© 2015 Elsevier Ltd.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Sexually transmitted viral infections represent a major public health concern due to lack of effective prevention strategies. Efforts are ongoing to develop modalities that can enable simultaneous prevention of multiple sexually transmitted infections. In the present review, we discuss the potential of natural polyphenols to prevent sexually transmitted viral infections. The review gives an account of various in vitro and in vivo studies carried out on epigallocatechin gallate, theaflavins (black tea polyphenols), resveratrol, genistein and curcumin to highlight their potential to prevent sexually transmitted infections caused by HIV (human immunodeficiency virus), HSV (herpes simplex virus) and HPV (human papilloma virus).
AB - Sexually transmitted viral infections represent a major public health concern due to lack of effective prevention strategies. Efforts are ongoing to develop modalities that can enable simultaneous prevention of multiple sexually transmitted infections. In the present review, we discuss the potential of natural polyphenols to prevent sexually transmitted viral infections. The review gives an account of various in vitro and in vivo studies carried out on epigallocatechin gallate, theaflavins (black tea polyphenols), resveratrol, genistein and curcumin to highlight their potential to prevent sexually transmitted infections caused by HIV (human immunodeficiency virus), HSV (herpes simplex virus) and HPV (human papilloma virus).
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U2 - 10.1016/j.drudis.2015.10.019
DO - 10.1016/j.drudis.2015.10.019
M3 - Review article
C2 - 26546859
AN - SCOPUS:84969194832
SN - 1359-6446
VL - 21
SP - 333
EP - 341
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 2
ER -