Lipid changes after hormone replacement therapy for menopause

W. T. Kable, J. C. Gallagher, L. Nachtigall, D. Goldgar

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22 Scopus citations


Three regimens of hormone replacement therapy were administered to 62 postmenopausal women for a period of 12 weeks and evaluated for their effect on blood lipids. Each group was given a continuous dose of 0.625 mg of conjugated estrogens combined with either a continuous dose of 2.5 mg of medroxyprogesterone acetate or 5.0 mg of medroxyprogesterone acetate, or a cyclic dose of 5.0 mg of medroxyprogesterone acetate on days 17-28 of the cycle. After treatment there was a significant decrease in the total cholesterol (P <.0007) and low density lipoprotein cholesterol (P <.0001) together with a significant increase in high density lipoprotein cholesterol (P <.0029). There was no significant difference in the response of the blood lipids to the three hormone groups. Therefore, preference would depend on the combination that caused the least bleeding or amenorrhea.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology


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