Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations

Qing Yang Huang; Hui Shen; Hong Yi Deng; Theresa Conway; K. Michael Davies; Jin Long Li; Robert R. Recker; Hong Wen Deng

doi:10.1007/s10038-003-0053-z

Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations

Qing Yang Huang, Hui Shen, Hong Yi Deng, Theresa Conway, K. Michael Davies, Jin Long Li, Robert R. Recker, Hong Wen Deng

Department of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Genetic factors play an important role in osteoporosis and obesity, two serious public health problems in the world. We investigated the relationships between obesity-related phenotypes, bone mineral density (BMD) and the CA repeat polymorphism of the IL6 gene in two large independent samples using the quantitative transmission disequilibrium test (QTDT). The first sample consisted of 1,816 individuals from 79 multigenerational pedigrees. Each pedigree was identified through a proband with BMD Z-scores ≤ -1.28 at the hip or spine. The second sample was a randomly ascertained set of 636 individuals from 157 nuclear families. Ten alleles containing 9-18 CA repeats were identified in our Caucasian populations. For body mass index (BMI), fat mass and percentage fat mass (PFM), highly significant (P

Original language	English (US)
Pages (from-to)	430-437
Number of pages	8
Journal	Journal of Human Genetics
Volume	48
Issue number	8
DOIs	https://doi.org/10.1007/s10038-003-0053-z
State	Published - 2003

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1007/s10038-003-0053-z

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title = "Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations",

abstract = "Genetic factors play an important role in osteoporosis and obesity, two serious public health problems in the world. We investigated the relationships between obesity-related phenotypes, bone mineral density (BMD) and the CA repeat polymorphism of the IL6 gene in two large independent samples using the quantitative transmission disequilibrium test (QTDT). The first sample consisted of 1,816 individuals from 79 multigenerational pedigrees. Each pedigree was identified through a proband with BMD Z-scores ≤ -1.28 at the hip or spine. The second sample was a randomly ascertained set of 636 individuals from 157 nuclear families. Ten alleles containing 9-18 CA repeats were identified in our Caucasian populations. For body mass index (BMI), fat mass and percentage fat mass (PFM), highly significant (P",

author = "Huang, {Qing Yang} and Hui Shen and Deng, {Hong Yi} and Theresa Conway and Davies, {K. Michael} and Li, {Jin Long} and Recker, {Robert R.} and Deng, {Hong Wen}",

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AU - Huang, Qing Yang

AU - Shen, Hui

AU - Deng, Hong Yi

AU - Conway, Theresa

AU - Davies, K. Michael

AU - Li, Jin Long

AU - Recker, Robert R.

AU - Deng, Hong Wen

PY - 2003

Y1 - 2003

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AB - Genetic factors play an important role in osteoporosis and obesity, two serious public health problems in the world. We investigated the relationships between obesity-related phenotypes, bone mineral density (BMD) and the CA repeat polymorphism of the IL6 gene in two large independent samples using the quantitative transmission disequilibrium test (QTDT). The first sample consisted of 1,816 individuals from 79 multigenerational pedigrees. Each pedigree was identified through a proband with BMD Z-scores ≤ -1.28 at the hip or spine. The second sample was a randomly ascertained set of 636 individuals from 157 nuclear families. Ten alleles containing 9-18 CA repeats were identified in our Caucasian populations. For body mass index (BMI), fat mass and percentage fat mass (PFM), highly significant (P

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Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations

Abstract

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