@article{beb123bea1ec49b392316dc9d15f3664,
title = "Indole-2-carboxamides are active against mycobacterium abscessus in a mouse model of acute infection",
abstract = "Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.",
author = "Pandya, {Amit N.} and Prathipati, {Pavan K.} and Pooja Hegde and Wei Li and Graham, {Kyle F.} and Subhra Mandal and Drescher, {Kristen M.} and Destache, {Christopher J.} and Diane Ordway and Mary Jackson and Northa, {E. Jeffrey}",
note = "Funding Information: This project was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases research grant AI116525 and the Jack and Lois Ware-ham Research Award. The efficacy study was supported by the National Institutes of Health and the National Institute of Allergy and Infectious Diseases under contract no. HHSN272201100009I/HHSN27200004 A19. Publisher Copyright: Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",
year = "2019",
month = mar,
doi = "10.1128/AAC.02245-18",
language = "English (US)",
volume = "63",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "3",
}