TY - GEN
T1 - Homo- and hetero-oligomerization in the Slc26a protein family
AU - Currall, Benjamin
AU - Jensen-Smith, Heather
AU - Hallworth, Richard
PY - 2011
Y1 - 2011
N2 - The motor-protein prestin is thought to be a homo-oligomer, but the oligomerization motifs are unknown. We used the acceptor-photobleach variant of fluorescence-lifetime based FRET analysis to demonstrate that homo-oligomerization is not only common to mammalian and non-mammalian prestins, but occurs in widely divergent members of the Slc26a family proteins. We therefore tested the hypothesis that oligomerization is conserved across the Slc26a family by measuring FRET between different Slc26a family molecules. Our results show that hetero-oligomerization is common between family members, which suggest that common oligomerization motifs exist.
AB - The motor-protein prestin is thought to be a homo-oligomer, but the oligomerization motifs are unknown. We used the acceptor-photobleach variant of fluorescence-lifetime based FRET analysis to demonstrate that homo-oligomerization is not only common to mammalian and non-mammalian prestins, but occurs in widely divergent members of the Slc26a family proteins. We therefore tested the hypothesis that oligomerization is conserved across the Slc26a family by measuring FRET between different Slc26a family molecules. Our results show that hetero-oligomerization is common between family members, which suggest that common oligomerization motifs exist.
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U2 - 10.1063/1.3658077
DO - 10.1063/1.3658077
M3 - Conference contribution
AN - SCOPUS:82955240841
SN - 9780735409750
T3 - AIP Conference Proceedings
SP - 154
EP - 159
BT - What Fire is in Mine Ears
T2 - 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Y2 - 16 July 2011 through 22 July 2011
ER -