Hereditary malignant melanoma: A unifying etiologic hypothesis

Henry T. Lynch, Ramon M. Fusaro

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The recent increase in incidence of malignant melanoma in many of the "sun belts" of the world has focused intense interest on its etiology. Although sunlight is an important factor, only a fraction of those individuals exposed to significantly large amounts of sunlight develop malignant melanoma. Genetic susceptibility undoubtedly plays an important etiologic role. We have put forth a multifaceted hypothesis, which we believe provides unification for the genetic-environmental interaction in the etiology of malignant melanoma. Genetic heterogeneity in the familial atypical multiple mole melanoma (FAMMM) syndrome and other single gene disorders that predispose to malignant melanoma are particularly stressed. The possibility of polygenic or multifactorial factors in the etiology of malignant melanoma remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number3-4
StatePublished - Feb 15 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research


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