TY - JOUR
T1 - Future studies using histomorphometry in type 1 diabetes mellitus
AU - Graeff-Armas, Laura A.
AU - Silverman, Emily
AU - Recker, Robert R.
N1 - Funding Information:
Works cited in this review were supported by NIH Grant K23 AR055542 and the Health Future Foundation of Creighton University. Current grant support of RR and LGA includes NIH Grant R01DK122558.
Funding Information:
E.S. and L.G.A. report no conflicts of interest. R.R. reports grant funding from Amgen, Inc.
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Purpose of reviewThis article reviews the current state of research in type 1 diabetes and bone, focusing on human bone turnover markers and histomorphometry.Recent findingsBone turnover markers have been used for decades to document static bone turnover status in a variety of diseases but especially in diabetes. Two new studies focus on dynamic testing conditions to examine the acute effects of insulin and exercise on bone turnover. Publications of human bone histomorphometry in type 1 diabetes are few but there are several new studies currently underway.SummaryHere, we review the most recent literature on human bone turnover markers and histomorphometry. Low bone turnover is thought to be a major underlying factor in bone fragility in T1DM. Further studies in human transilial bone biopsies will be helpful in determining the mechanisms.
AB - Purpose of reviewThis article reviews the current state of research in type 1 diabetes and bone, focusing on human bone turnover markers and histomorphometry.Recent findingsBone turnover markers have been used for decades to document static bone turnover status in a variety of diseases but especially in diabetes. Two new studies focus on dynamic testing conditions to examine the acute effects of insulin and exercise on bone turnover. Publications of human bone histomorphometry in type 1 diabetes are few but there are several new studies currently underway.SummaryHere, we review the most recent literature on human bone turnover markers and histomorphometry. Low bone turnover is thought to be a major underlying factor in bone fragility in T1DM. Further studies in human transilial bone biopsies will be helpful in determining the mechanisms.
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U2 - 10.1097/MED.0000000000000644
DO - 10.1097/MED.0000000000000644
M3 - Review article
C2 - 34183539
AN - SCOPUS:85109677226
SN - 1752-296X
VL - 28
SP - 371
EP - 376
JO - Current Opinion in Endocrinology, Diabetes and Obesity
JF - Current Opinion in Endocrinology, Diabetes and Obesity
IS - 4
ER -