Functional indices of vitamin D status and ramifications of vitamin D deficiency.

Robert P. Heaney

Research output: Contribution to journalReview articlepeer-review

359 Scopus citations


Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D3 concentrations of <80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of approximately 1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations.

Original languageEnglish (US)
Pages (from-to)1706S-9S
JournalThe American journal of clinical nutrition
Issue number6 Suppl
StatePublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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