TY - JOUR
T1 - Early versus late surgical intervention or medical management for infective endocarditis
T2 - A systematic review and meta-analysis
AU - Narayanan, Mahesh Anantha
AU - Haddad, Toufik Mahfood
AU - Kalil, Andre C.
AU - Kanmanthareddy, Arun
AU - Suri, Rakesh M.
AU - Mansour, George
AU - Destache, Christopher J.
AU - Baskaran, Janani
AU - Mooss, Aryan N.
AU - Wichman, Tammy
AU - Morrow, Lee
AU - Vivekanandan, Renuga
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Objective Infective endocarditis is associated with high morbidity and mortality and optimal timing for surgical intervention is unclear. We performed a systematic review and meta-analysis to compare early surgical intervention with conservative therapy in patients with infective endocarditis. Methods PubMed, Cochrane, EMBASE, CINAHL and Google-scholar databases were searched from January 1960 to April 2015. Randomised controlled trials, retrospective cohorts and prospective observational studies comparing outcomes between early surgery at 20 days or less and conservative management for infective endocarditis were analysed. Results A total of 21 studies were included. OR of allcause mortality for early surgery was 0.61 (95% CI 0.50 to 0.74, p
AB - Objective Infective endocarditis is associated with high morbidity and mortality and optimal timing for surgical intervention is unclear. We performed a systematic review and meta-analysis to compare early surgical intervention with conservative therapy in patients with infective endocarditis. Methods PubMed, Cochrane, EMBASE, CINAHL and Google-scholar databases were searched from January 1960 to April 2015. Randomised controlled trials, retrospective cohorts and prospective observational studies comparing outcomes between early surgery at 20 days or less and conservative management for infective endocarditis were analysed. Results A total of 21 studies were included. OR of allcause mortality for early surgery was 0.61 (95% CI 0.50 to 0.74, p
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U2 - 10.1136/heartjnl-2015-308589
DO - 10.1136/heartjnl-2015-308589
M3 - Article
C2 - 26869640
AN - SCOPUS:84959090906
SN - 1355-6037
VL - 102
SP - 950
EP - 957
JO - Heart
JF - Heart
IS - 12
ER -