Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões; J. P. Rasigade; H. Lemriss; M. Butin; C. Ginevra; S. Lemriss; R. V. Goering; A. Ibrahimi; J. C. Picaud; S. El Kabbaj; F. Vandenesch; F. Laurent

doi:10.1128/AAC.01576-13

Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões, J. P. Rasigade, H. Lemriss, M. Butin, C. Ginevra, S. Lemriss, R. V. Goering, A. Ibrahimi, J. C. Picaud, S. El Kabbaj, F. Vandenesch, F. Laurent

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

Original language	English (US)
Pages (from-to)	6354-6357
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01576-13
State	Published - Dec 2013

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01576-13

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Simões, P. M., Rasigade, J. P., Lemriss, H., Butin, M., Ginevra, C., Lemriss, S., Goering, R. V., Ibrahimi, A., Picaud, J. C., El Kabbaj, S., Vandenesch, F., & Laurent, F. (2013). Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A. Antimicrobial agents and chemotherapy, 57(12), 6354-6357. https://doi.org/10.1128/AAC.01576-13

Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A. / Simões, P. Martins; Rasigade, J. P.; Lemriss, H. et al.

In: Antimicrobial agents and chemotherapy, Vol. 57, No. 12, 12.2013, p. 6354-6357.

Research output: Contribution to journal › Article › peer-review

Simões, PM, Rasigade, JP, Lemriss, H, Butin, M, Ginevra, C, Lemriss, S, Goering, RV, Ibrahimi, A, Picaud, JC, El Kabbaj, S, Vandenesch, F & Laurent, F 2013, 'Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A', Antimicrobial agents and chemotherapy, vol. 57, no. 12, pp. 6354-6357. https://doi.org/10.1128/AAC.01576-13

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abstract = "Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.",

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AU - Butin, M.

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AB - Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

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Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

Abstract

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