TY - JOUR
T1 - Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy
AU - Greenspan, Susan L.
AU - Perera, Subashan
AU - Recker, Robert
AU - Wagner, Julie M.
AU - Greeley, Parmatma
AU - Gomberg, Bryon R.
AU - Seaman, Pamela
AU - Kleerekoper, Michael
PY - 2010/4
Y1 - 2010/4
N2 - Purpose: In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy. Materials and methods: We followed 10 postmenopausal women receiving a bisphosphonate, risedronate (35 mg once weekly), over 12 months and examined trabecular microarchitecture with high resolution wrist MR images (hr-MRI). MRI parameters included bone volume/total volume (BV/TV), surface density (representing plates), curve density (representing rods), surface-to-curve ratio and erosion index (depicting deterioration). We assessed BMD of the spine, hip and radius and markers of bone turnover. Results: Women had been receiving bisphosphonate therapy for 43±9 months (mean±SD) prior to the first MRI. Indices of hr-MRI demonstrated improvement in surface-to-curve ratio (13.0%) and a decrease in erosion index (12.1%) consistent with less deterioration (both p
AB - Purpose: In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy. Materials and methods: We followed 10 postmenopausal women receiving a bisphosphonate, risedronate (35 mg once weekly), over 12 months and examined trabecular microarchitecture with high resolution wrist MR images (hr-MRI). MRI parameters included bone volume/total volume (BV/TV), surface density (representing plates), curve density (representing rods), surface-to-curve ratio and erosion index (depicting deterioration). We assessed BMD of the spine, hip and radius and markers of bone turnover. Results: Women had been receiving bisphosphonate therapy for 43±9 months (mean±SD) prior to the first MRI. Indices of hr-MRI demonstrated improvement in surface-to-curve ratio (13.0%) and a decrease in erosion index (12.1%) consistent with less deterioration (both p
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U2 - 10.1016/j.bone.2009.12.025
DO - 10.1016/j.bone.2009.12.025
M3 - Article
C2 - 20051275
AN - SCOPUS:77950532416
SN - 8756-3282
VL - 46
SP - 1006
EP - 1010
JO - Bone
JF - Bone
IS - 4
ER -