Bisphosphonate Drug Holidays and Fall Prevention in the Reduction of Postmenopausal Fractures

Bisphosphonates are commonly used as first-line agents in the treatment of postmenopausal bone fragility. Recently, concern has been raised regarding the risk of atypical fracture with long-term therapy. A potential solution to obtaining the benefits while minimizing the risks of bisphosphonate therapy is the use of a drug holiday, or temporary cessation of medication. For drug holidays to be an effective approach, patients must maintain fracture protection while off therapy. One way to optimize fracture protection during this time is to prevent falls. Risk of atypical fracture and bisphosphonate drug holiday will be discussed, along with a summary of the most effective fall prevention modalities.