Association of MS Pi phenotype with airway hyperresponsiveness

R. G. Townley; J. G. Southard; P. Radford; R. J. Hopp; A. K. Bewtra; L. Ford

doi:10.1378/chest.98.3.594

Association of MS Pi phenotype with airway hyperresponsiveness

R. G. Townley, J. G. Southard, P. Radford, R. J. Hopp, A. K. Bewtra, L. Ford

Department of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α₁-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.

Original language	English (US)
Pages (from-to)	594-599
Number of pages	6
Journal	Chest
Volume	98
Issue number	3
DOIs	https://doi.org/10.1378/chest.98.3.594
State	Published - 1990

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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abstract = "Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.",

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AU - Radford, P.

AU - Hopp, R. J.

AU - Bewtra, A. K.

AU - Ford, L.

PY - 1990

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AB - Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.

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Association of MS Pi phenotype with airway hyperresponsiveness

Abstract

All Science Journal Classification (ASJC) codes

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