Association of MS Pi phenotype with airway hyperresponsiveness

R. G. Townley, J. G. Southard, P. Radford, R. J. Hopp, A. K. Bewtra, L. Ford

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.

Original languageEnglish (US)
Pages (from-to)594-599
Number of pages6
Issue number3
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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