Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy

A. Cohen; D. W. Dempster; R. Müller; X. E. Guo; T. L. Nickolas; X. S. Liu; X. H. Zhang; A. J. Wirth; G. H. Van Lenthe; T. Kohler; D. J. McMahon; H. Zhou; M. R. Rubin; J. P. Bilezikian; J. M. Lappe; R. R. Recker; E. Shane

doi:10.1007/s00198-009-0945-7

Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy

A. Cohen, D. W. Dempster, R. Müller, X. E. Guo, T. L. Nickolas, X. S. Liu, X. H. Zhang, A. J. Wirth, G. H. Van Lenthe, T. Kohler, D. J. McMahon, H. Zhou, M. R. Rubin, J. P. Bilezikian, J. M. Lappe, R. R. Recker, E. Shane

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141 Scopus citations

Abstract

We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction: HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the "gold standard," transiliac bone biopsy. Methods: HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39±10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (μCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (μFE) of biopsy μCT and HR-pQCT images. Results: The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by μCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P

Original language	English (US)
Pages (from-to)	263-273
Number of pages	11
Journal	Osteoporosis International
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s00198-009-0945-7
State	Published - Feb 2010

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Endocrinology, Diabetes and Metabolism

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Cohen, A., Dempster, D. W., Müller, R., Guo, X. E., Nickolas, T. L., Liu, X. S., Zhang, X. H., Wirth, A. J., Van Lenthe, G. H., Kohler, T., McMahon, D. J., Zhou, H., Rubin, M. R., Bilezikian, J. P., Lappe, J. M., Recker, R. R., & Shane, E. (2010). Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy. Osteoporosis International, 21(2), 263-273. https://doi.org/10.1007/s00198-009-0945-7

Cohen, A, Dempster, DW, Müller, R, Guo, XE, Nickolas, TL, Liu, XS, Zhang, XH, Wirth, AJ, Van Lenthe, GH, Kohler, T, McMahon, DJ, Zhou, H, Rubin, MR, Bilezikian, JP, Lappe, JM , Recker, RR & Shane, E 2010, 'Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy', Osteoporosis International, vol. 21, no. 2, pp. 263-273. https://doi.org/10.1007/s00198-009-0945-7

@article{3dc9c245c832404d85c9bcb7d16d89b2,

title = "Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy",

abstract = "We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction: HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the {"}gold standard,{"} transiliac bone biopsy. Methods: HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39±10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (μCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (μFE) of biopsy μCT and HR-pQCT images. Results: The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by μCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P",

author = "A. Cohen and Dempster, {D. W.} and R. M{\"u}ller and Guo, {X. E.} and Nickolas, {T. L.} and Liu, {X. S.} and Zhang, {X. H.} and Wirth, {A. J.} and {Van Lenthe}, {G. H.} and T. Kohler and McMahon, {D. J.} and H. Zhou and Rubin, {M. R.} and Bilezikian, {J. P.} and Lappe, {J. M.} and Recker, {R. R.} and E. Shane",

note = "Funding Information: These studies are supported by the following NIH funding sources: AR49896, DK069350, and AR051376. ",

year = "2010",

month = feb,

doi = "10.1007/s00198-009-0945-7",

language = "English (US)",

volume = "21",

pages = "263--273",

journal = "Osteoporosis International",

issn = "0937-941X",

publisher = "Springer London",

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TY - JOUR

T1 - Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography

T2 - Comparison with transiliac bone biopsy

AU - Cohen, A.

AU - Dempster, D. W.

AU - Müller, R.

AU - Guo, X. E.

AU - Nickolas, T. L.

AU - Liu, X. S.

AU - Zhang, X. H.

AU - Wirth, A. J.

AU - Van Lenthe, G. H.

AU - Kohler, T.

AU - McMahon, D. J.

AU - Zhou, H.

AU - Rubin, M. R.

AU - Bilezikian, J. P.

AU - Lappe, J. M.

AU - Recker, R. R.

AU - Shane, E.

N1 - Funding Information: These studies are supported by the following NIH funding sources: AR49896, DK069350, and AR051376.

PY - 2010/2

Y1 - 2010/2

N2 - We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction: HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the "gold standard," transiliac bone biopsy. Methods: HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39±10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (μCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (μFE) of biopsy μCT and HR-pQCT images. Results: The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by μCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P

AB - We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction: HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the "gold standard," transiliac bone biopsy. Methods: HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39±10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (μCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (μFE) of biopsy μCT and HR-pQCT images. Results: The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by μCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P

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JO - Osteoporosis International

JF - Osteoporosis International

IS - 2

ER -

Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy

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