Analogs of the κ opioid receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opioid receptor affinity, selectivity and κ opioid receptor antagonism

Medicine & Life Sciences

• arodyn 100%
• Narcotic Antagonists 47%
• Opioid Receptors 44%
• Cyclization 30%
• Dynorphins 18%
• Peptides 12%
• Structure-Activity Relationship 7%
• Peptide Hydrolases 5%

Chemical Compounds

• Narcotic Antagonist 59%
• Ring Closing Metathesis 46%
• Cyclization Reaction 29%
• Peptide 23%
• Dynorphin A 21%
• Cis Isomer 14%
• Antagonist 12%
• Structure-Activity Relationship 11%
• Flexibility 10%
• Double Bond 10%
• Pharmacological Metabolism 10%
• Compound Isomer 9%