An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin

Marc Rendell; P. M. Stephen; Robert Paulsen; J. L. Valentine; Kathy Rasbold; Tim Hestorff; Susan Eastberg; Daniel C. Shint

doi:10.1016/0305-0491(85)90072-0

An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin

Marc Rendell, P. M. Stephen, Robert Paulsen, J. L. Valentine, Kathy Rasbold, Tim Hestorff, Susan Eastberg, Daniel C. Shint

Department of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

1. 1. Aminophenylboronic acid affinity chromatography was used to measure glycosylated hemoglobin and glycosylated albumin levels in a variety of species. 2. 2. The highest glycosylated hemoglobin levels were found in man, the lowest in the chicken and the pig. 3. 3. The highest glycosylated albumin levels were found in avian species, the lowest in the mouse and the rat. 4. 4. A simple kinetic model was used to analyze the rates of formation of glycosylated hemoglobin and albumin in the various species. 5. 5. Rates of glycosylated albumin formation were very similar across the species while rates of glycosylated hemoglobin formation were quite different, presumably reflecting wide differences in erythrocyte permeability to glucose among the species.

Original language	English (US)
Pages (from-to)	819-822
Number of pages	4
Journal	Comparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume	81
Issue number	4
DOIs	https://doi.org/10.1016/0305-0491(85)90072-0
State	Published - 1985

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Molecular Biology

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abstract = "1. 1. Aminophenylboronic acid affinity chromatography was used to measure glycosylated hemoglobin and glycosylated albumin levels in a variety of species. 2. 2. The highest glycosylated hemoglobin levels were found in man, the lowest in the chicken and the pig. 3. 3. The highest glycosylated albumin levels were found in avian species, the lowest in the mouse and the rat. 4. 4. A simple kinetic model was used to analyze the rates of formation of glycosylated hemoglobin and albumin in the various species. 5. 5. Rates of glycosylated albumin formation were very similar across the species while rates of glycosylated hemoglobin formation were quite different, presumably reflecting wide differences in erythrocyte permeability to glucose among the species.",

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T1 - An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin

AU - Rendell, Marc

AU - Stephen, P. M.

AU - Paulsen, Robert

AU - Valentine, J. L.

AU - Rasbold, Kathy

AU - Hestorff, Tim

AU - Eastberg, Susan

AU - Shint, Daniel C.

PY - 1985

Y1 - 1985

N2 - 1. 1. Aminophenylboronic acid affinity chromatography was used to measure glycosylated hemoglobin and glycosylated albumin levels in a variety of species. 2. 2. The highest glycosylated hemoglobin levels were found in man, the lowest in the chicken and the pig. 3. 3. The highest glycosylated albumin levels were found in avian species, the lowest in the mouse and the rat. 4. 4. A simple kinetic model was used to analyze the rates of formation of glycosylated hemoglobin and albumin in the various species. 5. 5. Rates of glycosylated albumin formation were very similar across the species while rates of glycosylated hemoglobin formation were quite different, presumably reflecting wide differences in erythrocyte permeability to glucose among the species.

AB - 1. 1. Aminophenylboronic acid affinity chromatography was used to measure glycosylated hemoglobin and glycosylated albumin levels in a variety of species. 2. 2. The highest glycosylated hemoglobin levels were found in man, the lowest in the chicken and the pig. 3. 3. The highest glycosylated albumin levels were found in avian species, the lowest in the mouse and the rat. 4. 4. A simple kinetic model was used to analyze the rates of formation of glycosylated hemoglobin and albumin in the various species. 5. 5. Rates of glycosylated albumin formation were very similar across the species while rates of glycosylated hemoglobin formation were quite different, presumably reflecting wide differences in erythrocyte permeability to glucose among the species.

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An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin

Abstract

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