AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump

Daniel J. Wolter; Nancy D. Hanson; Philip D. Lister

doi:10.1128/AAC.49.11.4763-4766.2005

AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump

Daniel J. Wolter, Nancy D. Hanson, Philip D. Lister

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

Original language	English (US)
Pages (from-to)	4763-4766
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	11
DOIs	https://doi.org/10.1128/AAC.49.11.4763-4766.2005
State	Published - Nov 2005

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.49.11.4763-4766.2005

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abstract = "Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.",

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AU - Hanson, Nancy D.

AU - Lister, Philip D.

PY - 2005/11

Y1 - 2005/11

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AB - Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.

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AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump

Abstract

All Science Journal Classification (ASJC) codes

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