TY - JOUR
T1 - A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
AU - Date, Abhijit A.
AU - Destache, Christopher J.
N1 - Funding Information:
This work was supported by National Institute of Health grants 1R56AI095115-01 (to C.J.D.). The authors have no conflict of interest.
PY - 2013/8
Y1 - 2013/8
N2 - Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.
AB - Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.
UR - http://www.scopus.com/inward/record.url?scp=84878661829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878661829&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2013.05.012
DO - 10.1016/j.biomaterials.2013.05.012
M3 - Review article
C2 - 23726227
AN - SCOPUS:84878661829
SN - 0142-9612
VL - 34
SP - 6202
EP - 6228
JO - Biomaterials
JF - Biomaterials
IS - 26
ER -