A large multisite cancer family is linked to BRCA2

P. Tonin; P. Ghadirian; C. Phelan; G. M. Lenoir; H. T. Lynch; F. Letendre; D. Belanger; M. Monté; S. A. Narod

doi:10.1136/jmg.32.12.982

A large multisite cancer family is linked to BRCA2

P. Tonin, P. Ghadirian, C. Phelan, G. M. Lenoir, H. T. Lynch, F. Letendre, D. Belanger, M. Monté, S. A. Narod

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58 Scopus citations

Abstract

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

Original language	English (US)
Pages (from-to)	982-984
Number of pages	3
Journal	Journal of Medical Genetics
Volume	32
Issue number	12
DOIs	https://doi.org/10.1136/jmg.32.12.982
State	Published - 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1136/jmg.32.12.982

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abstract = "We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.",

author = "P. Tonin and P. Ghadirian and C. Phelan and Lenoir, {G. M.} and Lynch, {H. T.} and F. Letendre and D. Belanger and M. Mont{\'e} and Narod, {S. A.}",

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AU - Tonin, P.

AU - Ghadirian, P.

AU - Phelan, C.

AU - Lenoir, G. M.

AU - Lynch, H. T.

AU - Letendre, F.

AU - Belanger, D.

AU - Monté, M.

AU - Narod, S. A.

PY - 1995

Y1 - 1995

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AB - We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

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A large multisite cancer family is linked to BRCA2

Abstract

All Science Journal Classification (ASJC) codes

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