A large multisite cancer family is linked to BRCA2

P. Tonin, P. Ghadirian, C. Phelan, G. M. Lenoir, H. T. Lynch, F. Letendre, D. Belanger, M. Monté, S. A. Narod

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

Original languageEnglish (US)
Pages (from-to)982-984
Number of pages3
JournalJournal of Medical Genetics
Issue number12
StatePublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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